Pharmacological Inhibition of HDAC6 Attenuates Endothelial Barrier Dysfunction Induced by Thrombin

BACKGROUND: Endothelial barrier dysfunction (EBD) involves microtubule disassembly and enhanced cell contractility. Histone deacetylase 6 (HDAC6) deacetylates α-tubulin, and thereby destabilizes microtubules. This study investigates a role for HDAC6 in EBD. METHODS: EBD was induced with thrombin±HDA...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Saito, Shigeki, Lasky, Joseph A., Guo, Weichao, Nguyen, Hong, Mai, Antonello, Danchuk, Svitlana, Sullivan, Deborah E., Shan, Bin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100403/
https://ncbi.nlm.nih.gov/pubmed/21531207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.04.075
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi