Pharmacological Inhibition of HDAC6 Attenuates Endothelial Barrier Dysfunction Induced by Thrombin

BACKGROUND: Endothelial barrier dysfunction (EBD) involves microtubule disassembly and enhanced cell contractility. Histone deacetylase 6 (HDAC6) deacetylates α-tubulin, and thereby destabilizes microtubules. This study investigates a role for HDAC6 in EBD. METHODS: EBD was induced with thrombin±HDA...

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Bibliographic Details
Main Authors: Saito, Shigeki, Lasky, Joseph A., Guo, Weichao, Nguyen, Hong, Mai, Antonello, Danchuk, Svitlana, Sullivan, Deborah E., Shan, Bin
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100403/
https://ncbi.nlm.nih.gov/pubmed/21531207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.04.075
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