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Leaky sodium channels from voltage sensor mutations in periodic paralysis, but not paramyotonia

BACKGROUND: Hypokalemic periodic paralysis (HypoPP) is associated with mutations in either the Ca(V)1.1 calcium channel or the Na(V)1.4 sodium channel. Some Na(V)1.4 HypoPP mutations have been shown to cause an anomalous inward current that may contribute to the attacks of paralysis. Herein, we test...

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書誌詳細
主要な著者: Francis, David G., Rybalchenko, Volodymyr, Struyk, Arie, Cannon, Stephen C.
フォーマット: Artigo
言語:Inglês
出版事項: Lippincott Williams & Wilkins 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100087/
https://ncbi.nlm.nih.gov/pubmed/21490317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0b013e318219fb57
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