Notch Signaling Pathway Enhances Bone Morphogenetic Protein 2 (BMP2) Responsiveness of Msx2 Gene to Induce Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells

Vascular calcification is regulated in a process similar to bone formation. BMP2 (bone morphogenetic protein 2) is essential for osteoblastic differentiation of mesenchymal progenitor cells and thus has been implicated in the development of vascular calcification. Here we examined whether Notch sign...

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Main Authors: Shimizu, Takehisa, Tanaka, Toru, Iso, Tatsuya, Matsui, Hiroki, Ooyama, Yoshiaki, Kawai-Kowase, Keiko, Arai, Masashi, Kurabayashi, Masahiko
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099727/
https://ncbi.nlm.nih.gov/pubmed/21471203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.175786
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