Runx2 Represses Myocardin-Mediated Differentiation and Facilitates Osteogenic Conversion of Vascular Smooth Muscle Cells

Phenotypic plasticity and the switching of vascular smooth muscle cells (SMCs) play a critical role in atherosclerosis. Although Runx2, a key osteogenic transcription factor, is expressed in atherosclerotic plaques, the molecular mechanisms by which Runx2 regulates SMC differentiation remain unclear...

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Main Authors: Tanaka, Toru, Sato, Hiroko, Doi, Hiroshi, Yoshida, Carolina A., Shimizu, Takehisa, Matsui, Hiroki, Yamazaki, Miki, Akiyama, Hideo, Kawai-Kowase, Keiko, Iso, Tatsuya, Komori, Toshihisa, Arai, Masashi, Kurabayashi, Masahiko
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223399/
https://ncbi.nlm.nih.gov/pubmed/18039851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01771-07
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