PIAS1 Mediates TGFβ-Induced SM α-Actin Gene Expression Through Inhibition of KLF4 Function-Expression by Protein Sumoylation

OBJECTIVE: TGFβ and proliferation/phenotypic switching of smooth muscle cells (SMCs) play a pivotal role in pathogenesis of atherosclerotic and restenotic lesions after angioplasty. We have previously shown that the protein inhibitor of activated STAT (PIAS)1 activates expression of SMC differentiat...

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Autori principali: Kawai-Kowase, Keiko, Ohshima, Takayuki, Matsui, Hiroki, Tanaka, Toru, Shimizu, Takehisa, Iso, Tatsuya, Arai, Masashi, Owens, Gary K., Kurabayashi, Masahiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322553/
https://ncbi.nlm.nih.gov/pubmed/18927467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.108.172700
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