Controlled Modulation of Folate Polyglutamyl Tail Length by Metabolic Engineering of Lactococcus lactis

The dairy starter bacterium Lactococcus lactis is able to synthesize folate and accumulates >90% of the produced folate intracellularly, predominantly in the polyglutamyl form. Approximately 10% of the produced folate is released into the environment. Overexpression of folC in L. lactis led to an...

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Autori principali: Sybesma, Wilbert, van den Born, Erwin, Starrenburg, Marjo, Mierau, Igor, Kleerebezem, Michiel, de Vos, Willem M., Hugenholtz, Jeroen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
Food Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC309937/
https://ncbi.nlm.nih.gov/pubmed/14660354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.69.12.7101-7107.2003
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