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Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
Activating AMPK or inactivating calcineurin slows ageing in Caenorhabditis elegans(1,2) and both have been implicated as therapeutic targets for age-related pathology in mammals(3–5). However, the direct targets that mediate their effects on longevity remain unclear. In mammals, CREB-regulated trans...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3098900/ https://ncbi.nlm.nih.gov/pubmed/21331044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09706 |
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