DNA Dynamics Is Likely to Be a Factor in the Genomic Nucleotide Repeats Expansions Related to Diseases

Trinucleotide repeats sequences (TRS) represent a common type of genomic DNA motif whose expansion is associated with a large number of human diseases. The driving molecular mechanisms of the TRS ongoing dynamic expansion across generations and within tissues and its influence on genomic DNA functio...

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Hauptverfasser: Alexandrov, Boian S., Valtchinov, Vlad I., Alexandrov, Ludmil B., Gelev, Vladimir, Dagon, Yossi, Bock, Jonathan, Kohane, Isaac S., Rasmussen, Kim Ø., Bishop, Alan R., Usheva, Anny
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098838/
https://ncbi.nlm.nih.gov/pubmed/21625483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019800
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