Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques

SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV m...

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Main Authors: Vanderford, Thomas H., Bleckwehl, Chelsea, Engram, Jessica C., Dunham, Richard M., Klatt, Nichole R., Feinberg, Mark B., Garber, David A., Betts, Michael R., Silvestri, Guido
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098234/
https://ncbi.nlm.nih.gov/pubmed/21625590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002048
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