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Estimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection

Mutations that allow SIV/HIV to avoid the cytotoxic T lymphocyte (CTL) response are well documented. Recently, there have been a few attempts at estimating the costs of CTL escape mutations in terms of the reduction in viral fitness and the killing rate at which the CTL response specific to one vira...

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Détails bibliographiques
Auteurs principaux: Ganusov, Vitaly V, De Boer, Rob J
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1420660/
https://ncbi.nlm.nih.gov/pubmed/16604188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020024
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