Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques

SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV m...

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Detalhes bibliográficos
Main Authors: Vanderford, Thomas H., Bleckwehl, Chelsea, Engram, Jessica C., Dunham, Richard M., Klatt, Nichole R., Feinberg, Mark B., Garber, David A., Betts, Michael R., Silvestri, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098234/
https://ncbi.nlm.nih.gov/pubmed/21625590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002048
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