Viral CTL Escape Mutants Are Generated in Lymph Nodes and Subsequently Become Fixed in Plasma and Rectal Mucosa during Acute SIV Infection of Macaques

SIV(mac239) infection of rhesus macaques (RMs) results in AIDS despite the generation of a strong antiviral cytotoxic T lymphocyte (CTL) response, possibly due to the emergence of viral escape mutants that prevent recognition of infected cells by CTLs. To determine the anatomic origin of these SIV m...

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Main Authors: Vanderford, Thomas H., Bleckwehl, Chelsea, Engram, Jessica C., Dunham, Richard M., Klatt, Nichole R., Feinberg, Mark B., Garber, David A., Betts, Michael R., Silvestri, Guido
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098234/
https://ncbi.nlm.nih.gov/pubmed/21625590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002048
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