Calpain-Catalyzed Proteolysis of Human dUTPase Specifically Removes the Nuclear Localization Signal Peptide

BACKGROUND: Calpain proteases drive intracellular signal transduction via specific proteolysis of multiple substrates upon Ca(2+)-induced activation. Recently, dUTPase, an enzyme essential to maintain genomic integrity, was identified as a physiological calpain substrate in Drosophila cells. Here we...

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Main Authors: Bozóky, Zoltán, Róna, Gergely, Klement, Éva, Medzihradszky, Katalin F., Merényi, Gábor, Vértessy, Beáta G., Friedrich, Peter
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098232/
https://ncbi.nlm.nih.gov/pubmed/21625588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019546
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