Activation of the cryptic DNA binding function of mutant forms of p53.

Ítems similars

• A direct effect of activated human p53 on nuclear DNA replication.
  per: Cox, L S, et al.
  Publicat: (1995)
• Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.
  per: Halazonetis, T D, et al.
  Publicat: (1993)
• SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53
  per: Demma, Mark, et al.
  Publicat: (2010)
• Restoration of DNA-Binding and Growth-Suppressive Activity of Mutant Forms of p53 Via a PCAF-Mediated Acetylation Pathway
  per: PEREZ, RICARDO E., et al.
  Publicat: (2010)
• Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53
  per: Zhao, Y, et al.
  Publicat: (2015)