Mitochondrial Changes in Ageing Caenorhabditis elegans – What Do We Learn from Superoxide Dismutase Knockouts?

One of the most popular damage accumulation theories of ageing is the mitochondrial free radical theory of ageing (mFRTA). The mFRTA proposes that ageing is due to the accumulation of unrepaired oxidative damage, in particular damage to mitochondrial DNA (mtDNA). Within the mFRTA, the “vicious cycle...

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Autori principali: Gruber, Jan, Ng, Li Fang, Fong, Sheng, Wong, Yee Ting, Koh, Soon Ann, Chen, Ce-Belle, Shui, Guanghou, Cheong, Wei Fun, Schaffer, Sebastian, Wenk, Markus R., Halliwell, Barry
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097207/
https://ncbi.nlm.nih.gov/pubmed/21611128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019444
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