Mitochondrial Changes in Ageing Caenorhabditis elegans – What Do We Learn from Superoxide Dismutase Knockouts?

One of the most popular damage accumulation theories of ageing is the mitochondrial free radical theory of ageing (mFRTA). The mFRTA proposes that ageing is due to the accumulation of unrepaired oxidative damage, in particular damage to mitochondrial DNA (mtDNA). Within the mFRTA, the “vicious cycle...

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Autores principales: Gruber, Jan, Ng, Li Fang, Fong, Sheng, Wong, Yee Ting, Koh, Soon Ann, Chen, Ce-Belle, Shui, Guanghou, Cheong, Wei Fun, Schaffer, Sebastian, Wenk, Markus R., Halliwell, Barry
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097207/
https://ncbi.nlm.nih.gov/pubmed/21611128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019444
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