Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model

Alzheimer Disease (AD) is a progressive neurological disorder characterized by the deposition of amyloid beta (Aβ), predominantly the Aβ(1–42) form, in the brain. Mitochondrial dysfunction and impaired energy metabolism are important components of AD pathogenesis. However, the causal and temporal re...

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Udgivet i:Sci Rep
Main Authors: Fong, Sheng, Teo, Emelyne, Ng, Li Fang, Chen, Ce-Belle, Lakshmanan, Lakshmi Narayanan, Tsoi, Sau Yee, Moore, Philip Keith, Inoue, Takao, Halliwell, Barry, Gruber, Jan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031964/
https://ncbi.nlm.nih.gov/pubmed/27653553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33781
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