Mitochondrial Changes in Ageing Caenorhabditis elegans – What Do We Learn from Superoxide Dismutase Knockouts?

One of the most popular damage accumulation theories of ageing is the mitochondrial free radical theory of ageing (mFRTA). The mFRTA proposes that ageing is due to the accumulation of unrepaired oxidative damage, in particular damage to mitochondrial DNA (mtDNA). Within the mFRTA, the “vicious cycle...

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Bibliographic Details
Main Authors: Gruber, Jan, Ng, Li Fang, Fong, Sheng, Wong, Yee Ting, Koh, Soon Ann, Chen, Ce-Belle, Shui, Guanghou, Cheong, Wei Fun, Schaffer, Sebastian, Wenk, Markus R., Halliwell, Barry
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3097207/
https://ncbi.nlm.nih.gov/pubmed/21611128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019444
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