The LMO2 T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell Development

The LMO2 gene encodes a LIM-only protein and is a target of chromosomal translocations in human T-cell leukemia. Recently, two X-SCID patients treated by gene therapy to rescue T-cell lymphopoiesis developed T-cell leukemias with retroviral insertion into the LMO2 gene causing clonal T-cell prolifer...

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Bibliografski detalji
Izdano u:Mol Cell Biol
Glavni autori: McCormack, Matthew P., Forster, Alan, Drynan, Lesley, Pannell, Richard, Rabbitts, Terence H.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2003
Teme:
Cell Growth and Development
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC309712/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645513/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.24.9003-9013.2003
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