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Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis

Chromosomal translocations are primary events in tumorigenesis. Those involving the mixed lineage leukaemia (MLL) gene are found in various guises and it is unclear whether MLL fusions can affect haematopoietic differentiation. We have used a model in which chromosomal translocations are generated i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Drynan, Lesley F, Pannell, Richard, Forster, Alan, Chan, Nicole M M, Cano, Florencia, Daser, Angelika, Rabbitts, Terence H
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1201345/
https://ncbi.nlm.nih.gov/pubmed/16096649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600760
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