While K-ras Is Essential for Mouse Development, Expression of the K-ras 4A Splice Variant Is Dispensable

In mammals, the three classical ras genes encode four highly homologous proteins, N-Ras, H-Ras, and the isoforms K-Ras 4A and 4B. Previous studies have shown that K-ras is essential for mouse development and that while K-ras 4A and 4B are expressed during development, K-ras 4A expression is regulate...

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Main Authors: Plowman, Sarah J., Williamson, D. James, O'Sullivan, Maureen J., Doig, Jennifer, Ritchie, Ann-Marie, Harrison, David J., Melton, David W., Arends, Mark J., Hooper, Martin L., Patek, Charles E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC309700/
https://ncbi.nlm.nih.gov/pubmed/14645534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.9245-9250.2003
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