Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways

K-ras mutations are found in 40–50% of human colorectal adenomas and carcinomas, but their functional contribution remains incompletely understood. Here, we show that a conditional mutant K-ras mouse model (K-ras(Asp12)/Cre), with transient intestinal Cre activation by β-Naphthoflavone (β-NF) treatm...

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Detalhes bibliográficos
Main Authors: Luo, Feijun, Brooks, David G, Ye, Hongtao, Hamoudi, Rifat, Poulogiannis, George, Patek, Charles E, Winton, Douglas J, Arends, Mark J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2768154/
https://ncbi.nlm.nih.gov/pubmed/19765110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2613.2009.00667.x
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