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Activation of K-RAS by co-mutation of codons 19 and 20 is transforming
The K-RAS oncogene is widely mutated in human cancers. Activating mutations in K-RAS give rise to constitutive signalling through the MAPK/ERK and PI3K/AKT pathways promoting increased cell division, reduced apoptosis and transformation. The majority of activating mutations in K-RAS are located in c...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056876/ https://ncbi.nlm.nih.gov/pubmed/21371307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-6-2 |
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