Penta-O-galloyl-β-D-glucose induces G(1 )arrest and DNA replicative S-phase arrest independently of P21 cyclin-dependent kinase inhibitor 1A, P27 cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple-negative xenograft growth

INTRODUCTION: Natural herbal compounds with novel actions different from existing breast cancer (BCa) treatment modalities are attractive for improving therapeutic efficacy and safety. We have recently shown that penta-1,2,3,4,6-O-galloyl-β-D-glucose (PGG) induced S-phase arrest in prostate cancer (...

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Bibliographische Detailangaben
Hauptverfasser: Chai, Yubo, Lee, Hyo-Jeong, Shaik, Ahmad Ali, Nkhata, Katai, Xing, Chengguo, Zhang, Jinhui, Jeong, Soo-Jin, Kim, Sung-Hoon, Lü, Junxuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096953/
https://ncbi.nlm.nih.gov/pubmed/20809980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2634
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