Structural Analysis of Human and Macaque Monoclonal Antibodies 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120

The quaternary neutralizing epitope (QNE) of HIV-1 gp120 is preferentially expressed on the trimeric envelope spikes of intact HIV virions, and QNE-specific monoclonal antibodies (mAbs) potently neutralize HIV-1. Here we present the crystal structures of the Fabs of human mAb 2909 and macaque mAb 2....

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Detaylı Bibliyografya
Asıl Yazarlar: Spurrier, Brett, Sampson, Jared M., Totrov, Maxim, Li, Huiguang, O'Neal, Timothy, Williams, Constance, Robinson, James, Gorny, Miroslaw K., Zolla-Pazner, Susan, Kong, Xiang-Peng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096878/
https://ncbi.nlm.nih.gov/pubmed/21565703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.02.012
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