Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models

Tumor-associated antigens (TAAs) include overexpressed self-antigens (e.g. Her2/neu) and tumor-virus antigens (e.g. HPV-16 E6/E7). Although in cancer patients, TAA-specific CD4+ and CD8+ cells are often present, they are not able to control tumor growth. In recent studies it became apparent that tum...

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Main Authors: Ying, Liu, Tuve, Sebastian, Persson, Jonas, Beyer, Ines, Yumul, Roma, Li, ZongYi, Tragoolpua, Kajornsak, Hellström, Karl-Erik, Roffler, Steve, Lieber, André
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096725/
https://ncbi.nlm.nih.gov/pubmed/21394107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2011.8
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