In situ adenovirus vaccination engages T effector cells against cancer

The efficacy of cancer-immunotherapy is limited because of central and peripheral immune-tolerance towards tumor-antigens. We propose a novel approach based on the fact that the immune-system has not evolved tolerance towards adenoviruses (Ads) and that Ads have not evolved efficient mechanisms for...

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Bibliografiska uppgifter
Huvudupphovsmän: Tuve, Sebastian, Liu, Ying, Tragoolpua, Khajornsak, Jacobs, Jeffrey Daniel, Yumul, Roma Christine, Li, Zong-Yi, Strauss, Robert, Hellström, Karl-Erik, Disis, Mary Leonora, Roffler, Steve, Lieber, André
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2727281/
https://ncbi.nlm.nih.gov/pubmed/19481312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.03.074
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