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Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors

Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer that has been the most common and most fatal cancer worldwide. Gefitinib (Iressa™) and erlotinib (Tarceva™), specific tyrosine kinase inhibitors (TKI) for the epidermal growth factor receptor (EGFR), have been demonstrated to be ef...

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Bibliografiske detaljer
Hovedforfatter: Gotoh, Noriko
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096503/
https://ncbi.nlm.nih.gov/pubmed/21594003
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