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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells

The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes, and its inhibition may explain the increased incidence of cardiomyopathy associated with the anti-HER2 monoclonal antibody trastuzumab (Genentech, South San Francisco, CA), particularly in patients...

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Detalhes bibliográficos
Main Authors: Spector, Neil L., Yarden, Yosef, Smith, Bradley, Lyass, Ljuba, Trusk, Patricia, Pry, Karen, Hill, Jason E., Xia, Wenle, Seger, Rony, Bacus, Sarah S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965560/
https://ncbi.nlm.nih.gov/pubmed/17556544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701286104
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