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Involvement of the DNA Repair Protein hHR23 in p53 Degradation

The stability of the tumor suppressor protein p53 is regulated via the ubiquitin-proteasome-dependent proteolytic pathway. Like most substrates of this pathway, p53 is modified by the attachment of polyubiquitin chains prior to proteasome-mediated degradation. However, the mechanism(s) involved in t...

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Autors principals: Glockzin, Sandra, Ogi, Francois-Xavier, Hengstermann, Arnd, Scheffner, Martin, Blattner, Christine
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC309646/
https://ncbi.nlm.nih.gov/pubmed/14645509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.8960-8969.2003
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