Growth Suppression by Acute Promyelocytic Leukemia-Associated Protein PLZF Is Mediated by Repression of c-myc Expression

The transcriptional repressor PLZF was identified by its translocation with retinoic acid receptor alpha in t(11;17) acute promyelocytic leukemia (APL). Ectopic expression of PLZF leads to cell cycle arrest and growth suppression, while disruption of normal PLZF function is implicated in the develop...

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Главные авторы: McConnell, Melanie J., Chevallier, Nathalie, Berkofsky-Fessler, Windy, Giltnane, Jena M., Malani, Rupal B., Staudt, Louis M., Licht, Jonathan D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2003
Предметы:
Transcriptional Regulation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC309637/
https://ncbi.nlm.nih.gov/pubmed/14645547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.9375-9388.2003
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