Dual inhibition of Akt/mTOR pathway by nab-rapamycin and perifosine induces anti-tumor activity in multiple myeloma

The PI3K/Akt/mTOR pathway mediates multiple myeloma (MM) cell proliferation, survival, and development of drug resistance, underscoring the role of mTOR inhibitors such as rapamycin with potential anti-MM activity. However, recent data demonstrate a positive feedback loop from mTOR/S6K1 to Akt, wher...

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Hauptverfasser: Cirstea, Diana, Hideshima, Teru, Rodig, Scott, Santo, Loredana, Pozzi, Samantha, Vallet, Sonia, Ikeda, Hiroshi, Perrone, Giulia, Patel, Kishan, Desai, Neil, Sportelli, Peter, Kapoor, Shweta, Vali, Shireen, Mukherjee, Siddhartha, Munshi, Nikhil C., Anderson, Kenneth C., Raje, Noopur
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096071/
https://ncbi.nlm.nih.gov/pubmed/20371718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0763
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