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Mass spectrometric analysis and mutagenesis predict involvement of multiple cysteines in redox regulation of the skeletal muscle ryanodine receptor ion channel complex

The tetrameric skeletal muscle ryanodine receptor ion channel complex (RyR1) contains a large number of free cysteines that are potential targets for redox-active molecules. Here, we report the mass spectrometric analysis of free thiols in RyR1 using the lipophilic, thiol-specific probe monobromobim...

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Tallennettuna:
Bibliografiset tiedot
Päätekijät: Petrotchenko, Evgeniy V, Yamaguchi, Naohiro, Pasek, Daniel A, Borchers, Christoph H, Meissner, Gerhard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095966/
https://ncbi.nlm.nih.gov/pubmed/21603587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/RRB.S15776
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