c-Jun N-Terminal Kinase 1 Promotes Transforming Growth Factor–β1–Induced Epithelial-to-Mesenchymal Transition via Control of Linker Phosphorylation and Transcriptional Activity of Smad3

Transforming growth factor (TGF)–β1 is a key mediator of lung remodeling and fibrosis. Epithelial cells are both a source of and can respond to TGF-β1 with epithelial-to-mesenchymal transition (EMT). We recently determined that TGF-β1–induced EMT in lung epithelial cells requires the presence of c-J...

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Main Authors: Velden, Jos L. J. van der, Alcorn, John F., Guala, Amy S., Badura, Elsbeth C. H. L., Janssen-Heininger, Yvonne M. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3095928/
https://ncbi.nlm.nih.gov/pubmed/20581097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2009-0282OC
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