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Testing the role of P2X(7) receptors in the development of type 1 diabetes in NOD mice

While P2rx7 has been proposed as a type 1 diabetes (T1D) susceptibility gene in NOD mice, its potential pathogenic role has not been directly determined. To test this possibility, we generated a new NOD stock deficient in P2X(7) receptors. T1D development was not altered by P2X(7) ablation. Previous...

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Detalhes bibliográficos
Main Authors: Chen, Yi-Guang, Scheuplein, Felix, Driver, John P., Hewes, Amanda A., Reifsnyder, Peter C., Leiter, Edward H., Serreze, David V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094905/
https://ncbi.nlm.nih.gov/pubmed/21357538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003733
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