Days-to-criterion as an indicator of toxicity associated with human Alzheimer amyloid-β oligomers

OBJECTIVES: Recent evidence suggests that high molecular weight soluble oligomeric Aβ (oAβ) assemblies (also known as Aβ-derived diffusible ligands, or ADDLs) may represent a primary neurotoxic basis for cognitive failure in AD. To date, in vivo studies of oAβ/ADDLs have involved injection of assemb...

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Main Authors: Gandy, Sam, Simon, Adam J., Steele, John W., Lublin, Alex L., Lah, James J., Walker, Lary C., Levey, Allan I., Krafft, Grant A., Levy, Efrat, Checler, Frédéric, Glabe, Charles, Bilker, Warren, Abel, Ted, Schmeidler, James, Ehrlich, Michelle E.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094694/
https://ncbi.nlm.nih.gov/pubmed/20641005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22052
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