SPARC downregulation attenuates the profibrogenic response of hepatic stellate cells induced by TGF-β(1) and PDGF

Liver fibrosis is an active process that involves changes in cell-cell and cell-extracellular matrix (ECM) interaction. Secreted protein, acidic and rich in cysteine (SPARC) is an ECM protein with many biological functions that is overexpressed in cirrhotic livers and upregulated in activated hepati...

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Detalhes bibliográficos
Main Authors: Atorrasagasti, Catalina, Aquino, Jorge B., Hofman, Leonardo, Alaniz, Laura, Malvicini, Mariana, Garcia, Mariana, Benedetti, Lorena, Friedman, Scott L., Podhajcer, Osvaldo, Mazzolini, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094149/
https://ncbi.nlm.nih.gov/pubmed/21311029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00316.2010
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