PDGF receptor-α promotes TGF-β signaling in hepatic stellate cells via transcriptional and posttranscriptional regulation of TGF-β receptors

Platelet-derived growth factor (PDGF) and transforming growth factor-β (TGF-β) signaling are required for hepatic stellate cell (HSC) activation under pathological conditions such as liver metastatic tumor growth. These two signaling pathways are functionally divergent; PDGF signaling promotes proli...

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Hlavní autoři: Liu, Chunsheng, Li, Jiachu, Xiang, Xiaoyu, Guo, Luyang, Tu, Kangsheng, Liu, Qinghua, Shah, Vijay H., Kang, Ningling
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
Témata:
Liver and Biliary Tract
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187064/
https://ncbi.nlm.nih.gov/pubmed/25169976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00138.2014
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