Modulation of sarcoplasmic reticulum Ca(2+) release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1

In vitro, calmodulin (CaM) and S100A1 activate the skeletal muscle ryanodine receptor ion channel (RyR1) at submicromolar Ca(2+) concentrations, whereas at micromolar Ca(2+) concentrations, CaM inhibits RyR1. One amino acid substitution (RyR1-L3625D) has previously been demonstrated to impair CaM bi...

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Detalhes bibliográficos
Main Authors: Yamaguchi, Naohiro, Prosser, Benjamin L., Ghassemi, Farshid, Xu, Le, Pasek, Daniel A., Eu, Jerry P., Hernández-Ochoa, Erick O., Cannon, Brian R., Wilder, Paul T., Lovering, Richard M., Weber, David, Melzer, Werner, Schneider, Martin F., Meissner, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093939/
https://ncbi.nlm.nih.gov/pubmed/21289290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00370.2010
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