Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (GEFs) p115, PDZ-RhoGEF (PRG), and Leukemia-associated RhoGEF (LARG)

The multimodular guanine nucleotide exchange factors (GEFs) of the Dbl family mostly share a tandem Dbl homology (DH) and pleckstrin homology (PH) domain organization. The function of these and other domains in the DH-mediated regulation of the GDP/GTP exchange reaction of the Rho proteins is the su...

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Main Authors: Jaiswal, Mamta, Gremer, Lothar, Dvorsky, Radovan, Haeusler, Lars Christian, Cirstea, Ion C., Uhlenbrock, Katharina, Ahmadian, Mohammad Reza
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093892/
https://ncbi.nlm.nih.gov/pubmed/21454492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.226431
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