Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I: A SINGLE, UNIFIED MECHANISM THAT APPLIES DURING BOTH FORWARD AND REVERSE ELECTRON TRANSFER

NADH:ubiquinone oxidoreductase (complex I) is a major source of reactive oxygen species in mitochondria and a contributor to cellular oxidative stress. In isolated complex I the reduced flavin is known to react with molecular oxygen to form predominantly superoxide, but studies using intact mitochon...

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Bibliografiska uppgifter
Huvudupphovsmän: Pryde, Kenneth R., Hirst, Judy
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Bioenergetics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093879/
https://ncbi.nlm.nih.gov/pubmed/21393237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.186841
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