Control of mitochondrial superoxide production by reverse electron transport at complex I

The generation of mitochondrial superoxide (O(2)(˙̄)) by reverse electron transport (RET) at complex I causes oxidative damage in pathologies such as ischemia reperfusion injury, but also provides the precursor to H(2)O(2) production in physiological mitochondrial redox signaling. Here, we quantifie...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Robb, Ellen L., Hall, Andrew R., Prime, Tracy A., Eaton, Simon, Szibor, Marten, Viscomi, Carlo, James, Andrew M., Murphy, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016480/
https://ncbi.nlm.nih.gov/pubmed/29743240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003647
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