Identification of Luminal Loop 1 of Scap Protein as the Sterol Sensor That Maintains Cholesterol Homeostasis

Cellular cholesterol homeostasis is maintained by Scap, an endoplasmic reticulum (ER) protein with eight transmembrane helices. In cholesterol-depleted cells, Scap transports sterol regulatory element-binding proteins (SREBPs) to the Golgi, where the active fragment of SREBP is liberated by protease...

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Main Authors: Motamed, Massoud, Zhang, Yinxin, Wang, Michael L., Seemann, Joachim, Kwon, Hyock Joo, Goldstein, Joseph L., Brown, Michael S.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
主題:
Membrane Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093874/
https://ncbi.nlm.nih.gov/pubmed/21454655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238311
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