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PKA and Epac synergistically inhibit smooth muscle cell proliferation

Cyclic AMP signalling promotes VSMC quiescence in healthy vessels and during vascular healing following injury. Cyclic AMP inhibits VSMC proliferation via mechanisms that are not fully understood. We investigated the role of PKA and Epac signalling on cAMP-induced inhibition of VSMC proliferation. c...

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Detalhes bibliográficos
Main Authors: Hewer, Richard C., Sala-Newby, Graciela B., Wu, Yih-Jer, Newby, Andrew C., Bond, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093616/
https://ncbi.nlm.nih.gov/pubmed/20971121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.10.010
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