PKA and Epac synergistically inhibit smooth muscle cell proliferation

Cyclic AMP signalling promotes VSMC quiescence in healthy vessels and during vascular healing following injury. Cyclic AMP inhibits VSMC proliferation via mechanisms that are not fully understood. We investigated the role of PKA and Epac signalling on cAMP-induced inhibition of VSMC proliferation. c...

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Detalles Bibliográficos
Autores principales: Hewer, Richard C., Sala-Newby, Graciela B., Wu, Yih-Jer, Newby, Andrew C., Bond, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: Academic Press 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093616/
https://ncbi.nlm.nih.gov/pubmed/20971121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.10.010
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