A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03

Romidepsin, a potent histone deacetylase inhibitor, has shown activity in preclinical glioma models. The primary objectives of this trial were to determine the pharmacokinetics of romidepsin in patients with recurrent glioma on enzyme-inducing antiepileptic drugs (EIAEDs) and to evaluate the antitum...

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Autores principales: Iwamoto, Fabio M., Lamborn, Kathleen R., Kuhn, John G., Wen, Patrick Y., Alfred Yung, W.K., Gilbert, Mark R., Chang, Susan M., Lieberman, Frank S., Prados, Michael D., Fine, Howard A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2011
Materias:
Clinical Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093337/
https://ncbi.nlm.nih.gov/pubmed/21377994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor017
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