Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells

High grade gliomas (HGGs) are characterized by resistance to radiotherapy and chemotherapy. Targeting Rad51-dependent homologous recombination repair may be an effective target for chemo- and radiosensitization. In this study we assessed the role of Rad51-dependent repair on sensitivity to radiation...

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Bibliographische Detailangaben
Hauptverfasser: Short, Susan C., Giampieri, Silvia, Worku, Mulugeta, Alcaide-German, Marisa, Sioftanos, George, Bourne, Sara, Lio, Ka Ian, Shaked-Rabi, Maya, Martindale, Christine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2011
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093331/
https://ncbi.nlm.nih.gov/pubmed/21363882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor010
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