A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

Dicer is a central enzyme in microRNA (miRNA) processing. We identified a Dicer-independent miRNA biogenesis pathway that uses Argonaute2 (Ago2) slicer catalytic activity. In contrast to other miRNAs, miR-451 levels were refractory to dicer loss of function but were reduced in MZago2 (maternal-zygot...

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Hauptverfasser: Cifuentes, Daniel, Xue, Huiling, Taylor, David W., Patnode, Heather, Mishima, Yuichiro, Cheloufi, Sihem, Ma, Enbo, Mane, Shrikant, Hannon, Gregory J., Lawson, Nathan D., Wolfe, Scot A., Giraldez, Antonio J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093307/
https://ncbi.nlm.nih.gov/pubmed/20448148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190809
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