A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity

Dicer is a central enzyme in microRNA (miRNA) processing. We identified a Dicer-independent miRNA biogenesis pathway that uses Argonaute2 (Ago2) slicer catalytic activity. In contrast to other miRNAs, miR-451 levels were refractory to dicer loss of function but were reduced in MZago2 (maternal-zygot...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cifuentes, Daniel, Xue, Huiling, Taylor, David W., Patnode, Heather, Mishima, Yuichiro, Cheloufi, Sihem, Ma, Enbo, Mane, Shrikant, Hannon, Gregory J., Lawson, Nathan D., Wolfe, Scot A., Giraldez, Antonio J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093307/
https://ncbi.nlm.nih.gov/pubmed/20448148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190809
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg