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Identification of a Polo-like Kinase 4-Dependent Pathway for De Novo Centriole Formation
Supernumerary centrosomes are a key cause of genomic instability in cancer cells [1]. New centrioles can be generated by duplication using a mother centriole as a platform or in the absence of preexisting centrioles by formation de novo [2]. Polo-like kinase 4 (Plk4) regulates both modes of centriol...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093158/ https://ncbi.nlm.nih.gov/pubmed/21353560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2011.01.072 |
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